Licorice: Licorice is also known as Radix Glycyrrhizae or Liquiritiae Radix. It is the root of Glycyrrhiza uralensis Fisch. ex DC., G. glabra L. or G. inflata Bat., Leguminosae [10,11].is the extract of Glycyrrhiza glabra roots. Glycyrrhiza licorice appears to have modest glucocorticoid activity and may act synergistically with cortisol. Components of licorice (primarily glycyrrhizin, which is structurally similar to corticoids) can bind to glucocorticoid and mineralocorticoid receptors, weakly mimicking the role of endogenous steroid hormones. There is some evidence that licorice may also reduce the breakdown of hydrocortisone to inactive cortisol products. Origin: It is native to Europe and Asia. The plant is actually classified as a weed in those areas. The early Egyptians loved licorice root. They used it in tea as a cure-all concoction. Licorice was later imported to China where it became an important herb in Chinese medicinal tradition. Chemical Constituent: Phytochemical analysis of licorice root extract exhibited that it contained flavonoids (isoflavonoids, formononetin, and liquiritin), saponin triterpenes (liquirtic acid and glycyrrhizin), and other components such as sugars, coumarins, amino acids, starch, tannins, phytosterols, choline, and vitamins (e.g., ascorbic acid). Previous reports have shown that more than 20 triterpenoids and 300 flavonoids have been procured from licorice. Glycyrrhizin constitutes up to 25% of the licorice root extract. Glycyrrhizin consists of glucuronic acid (two molecules) and glycyrrhetinic acid (one molecule). Traditional Usages: In ancient times, Glycyrrhiza was used as a medicine and flavouring herb. It is a soothing herb that enhances various body functions, protects the liver and is used in various conditions, such as mouth ulcers and arthritis, and as a potent anti-inflammatory, immunomodulatory, hepatoprotective, detoxifying, anti-cancer, anti-aging, antioxidant, antimicrobial, with growth promoting effects..